At the end of Toni Morrison's Beloved, widow and former slave Sethe mourns the loss of of her youngest child nearly two decades after her daughter's passing, and soon after her daughter's ghost has disappeared after re-entering her life for a time. Having lost her daughter twice at this point, she is overcome with guilt and states that she has lost her best thing.
Sometimes I think about Madison being gone and feel like I've lost my best thing too. It's like I was only flirting with loneliness before, but now I really know what it means. And nothing seems to make as much sense as it used to. Loss is the worst and grief, I suppose, is a necessary hassle.